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Finally, dietary glutamine increased the number of IgA-secreting B cells in the small intestine of young mice (156) and enhanced intestinal levels of IgA in various weaning animals (157161)

These findings tightly link ROS and Nrf2 to ER oxidative protein folding and calcium signaling, establishing a regulatory mechanism for protein oxidative folding-Nrf2-ER calcium axis (Figure 7)