GW 4064 late Borthakur A

Borthakur A

Chemical Name: 5-chloro-4-(1H-indol-3-yl)-N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidin-2-amine

Smiles: [2H]C1(C(=O)N2CC3C4=CC=CC=C4CCN3C(=O)C2)C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H]

Solubility: DMSO: 109 mg/mL(199

Although the exact mechanism of action is unknown

GW 4064 late Borthakur AGW 4064 is a selective agonist of FXR (EC50 = 15 nM). It displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 M. GW 4064 upregulates adipokine expression in preadipocytes and HepG2 cells. GW4064 could reduce induction of proinflammatory cytokines by LPS in vitro. Product information CAS Number: 278779 30 9 Molecular Weight: 542. 84 Formula: C28H22Cl3NO4 Chemical Name: 3 [(E) 2 (2 chloro 4 {[3