Aprepitant 126(ZZ) It has good activity against

It has good activity against a range of HCV genotype variants

4S)-3-{2-[(1R

only in cells with wild-type p53 such as HCT116

InChiKey: MJIHNNLFOKEZEW-RUZDIDTESA-N

Selective for Bcr-abl over a panel of serine

Aprepitant 126(ZZ) It has good activity againstAprepitant is a small molecule, high affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P induced emesis. This agent has little or no affinity for serotonin type 3 (5 HT3), dopamine, and corticosteroid receptors.