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Initial research indicates that ferroptosis could be a primary mechanism responsible for OAs death of chondrocytes and synoviocytes (Miao et al., 2022

doi: 10.1007/s40261-017-0564-6 16 de JagerJKooyALehertPWulffelMGvan der KolkJBetsDet al

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125 AGI-6780 treatment, binding with IDH2 or mutant IDH2 in an allosteric manner at the dimer interface, reduce the IDH2 activity and lead to the repression of cell growth in lung cancer