INCB3344 - CAS# 1262238-11-8 Size:Solid 2 mg InChi: InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2

InChi: InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2

778270-11-4

as measured by decreased kynurenine levels (>50%) in plasma and dose dependent efficacy in mice bearing GM-CSF-secreting B16 melanoma tumors

Smiles: O=C(CC(C1C=CC=CC=1)C1C=CC=CC=1)N1CCN(CC1)C(C1C=CC=CC=1)C1C=CC=CC=1

Trimetrexate is a quinazoline derivative

INCB3344 - CAS# 1262238-11-8 Size:Solid 2 mg InChi: InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2INCB3344 is a potent and selective antagonist of CCR2 receptor with IC(50) values of 5. 1 nM (hCCR2) and 9. 5 nM (mCCR2) in binding antagonism and 3. 8 nM (hCCR2) and 7. 8 nM (mCCR2) in antagonism of chemotaxis activity. INCB3344 exhibited >100 fold selectivity over other homologous chemokine receptors, a free fraction of 24% in human serum and 15% in mouse serum, and an oral bioavailability of 47% in mice, suitable as a tool compound for target