D-Sphingosine - CAS# 123-78-4 Catalog No.:M6801-2 898562-94-2

898562-94-2

ClH/c13-7-10-8-3-1-4-9(16-6-2-5-14)11(8)12(15)17-10

The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins

PubMed PMID: 17018630

Regulation of circadian behavior and metabolism by synthetic REV-ERB agonists

D-Sphingosine - CAS# 123-78-4 Catalog No.:M6801-2 898562-94-2D Sphingosine, CAS No. 123 78 4, is formed primarily from the breakdown of ceramide. Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase. D sphingosine, a lipid possessing the same hydrophobic base as ceramide but without a carbohydrate residue, efficiently blocked this glycolipid antigen presentation both in vitro and in spinal cords of EAE mice, and significantly decreased IL 17 and ameliorated the pathological symptoms.