Roflumilast Catalog No.:M8517-10 9 nM in MDA-MB-231 cells

9 nM in MDA-MB-231 cells

Chemical Name: methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methoxy-4-oxobutanamido]-5-methoxy-5-oxopentanamido]-3-methylbutanamido]-5-fluoro-4-oxopentanoate

Most phosphorylation events downstream of Syk are inhibited with similar potency by R112

Epub 2013 Mar 29

Chemical Name:    (2R

Roflumilast Catalog No.:M8517-10 9 nM in MDA-MB-231 cellsRoflumilast is a drug which acts as a selective, long acting inhibitor of the enzyme PDE 4. It has anti inflammatory effects and is under development as an orally administered drug for the treatment of inflammatory conditions of the lungs such as asthma, and chronic obstructive pulmonary disease (COPD). In June 2010, Daxas was approved in the EU for severe COPD associated with chronic bronchitis.[9] In March 2011, Daliresp gained FDA approval in the