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XL019 - CAS# 945755-56-6 nin 53(4):1509-18

XL019 - CAS# 945755-56-6 nin 53(4):1509-18

Name: XL019 - CAS# 945755-56-6 nin 53(4):1509-18
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XL019 - CAS# 945755-56-6 nin 53(4):1509-18XL019 is an orally bioavailable inhibitor of Janus associated kinase 2 (JAK2) with potential antineoplastic activity. XL019 inhibits the activation of JAK2 as well as the mutated form JAK2V617F, which may result in the inhibition of the JAK STAT signaling pathway and may induce apoptosis. The JAK2 mutated form JAK2V617F has a valine to phenylalanine modification at position 617 and plays a key role in tumor cell proliferation and survival. Product

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Description

53(4):1509-18

Chemical Name: N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2

J Cardiovasc Pharmacol

4*+1/p-4/b24-12-

1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate

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