Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 Catalog No.:M60005-10S At higher concentrations
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Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 Catalog No.:M60005-10S At higher concentrationsWnt C59, CAS No. 1243243 89 1, is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It prevents palmitylation of Wnt proteins by Porcupine (a membrane bound O acyltransferase), thereby blocking Wnt protein secretion and activity. Wnt C59 displayed good bioavailability as once daily oral administration and blocked progression of mammary tumors in MMTV WNT1 transgenic mice model while
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