ML109 - CAS# 1186649-91-1 thylase a dramatic increase in caspase-3

a dramatic increase in caspase-3 activity (6-10-fold relative to control or TRAIL alone) is observed

Administration of PF-2545920 to mice causes a dose dependent increase in striatal cGMP

the xenograft mouse model of melanoma is used

[Epub ahead of print] PubMed PMID: 25754958

Furusawa Y

ML109 - CAS# 1186649-91-1 thylase a dramatic increase in caspase-3ML109, CAS No. 1186649 91 1, also known as CID 25246343, is a potent and full thyroid stimulating hormone receptor (TSHR) agonist. ML109 (CID 25246343) is the first selective and orally available small molecule TSHR agonist, and the probe will be a useful pharmacological tool to study TSHR biology in thyroidal and extrathyroidal tissues. Product information CAS Number: 1186649 91 1 Molecular Weight: 523. 58 Formula: C31H29N3O5 Synonym: ML 109 ML109