FK506 monohydrate - CAS# 109581-93-3 60215 SAG induces Hedgehog pathway activation

SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells and counteracts Cyclopamine-KAAD inhibition of Smo

Tasisulam also inhibits VEGF-

a hypoxia-activated prodrug

MacDonald PE

2014 Mar 3

FK506 monohydrate - CAS# 109581-93-3 60215 SAG induces Hedgehog pathway activationFK506 monohydrate, CAS No. 109581 93 3, is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T lymphocytes in response to antigenic or mitogenic stimulation in vitro. Product information CAS Number: 109581 93 3 Molecular Weight: 822. 03 Formula: C44H71NO13 Synonym: FR 900506 FR900506 Tacrolimus FK506 monohydrate LCP Tacro Tacrolimus