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Methods Network-based identification of natural products Construction of the AD-related pathway-gene network In this study, we aimed to screen AD-related pathways from three perspectives: Most Studied Pathways (pathways with the most literature on AD), Gene-Associated Pathways (derived from AD-associated gene enrichment analysis), and Popular Pathways (pathways showing an increasing trend in the literature)

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Melasma : This is a complex and stubborn type of pigmentation that is a result of hormonal dysregulation and sun exposure

Methods: We use mathematical models for hepatic glutathione metabolism, including one-carbon metabolism and acetaminophen detoxification, to investigate how the activation of certain enzymes by estradiol leads to dramatic changes in reaction velocities and metabolite concentrations