PF06447475 - CAS# 1527473-33-1 0197 3-d]pyrimidin-4-ol

3-d]pyrimidin-4-ol

In combination with an angiogenesis inhibitor

Org Biomol Chem

highly potent and selective BMP pathway inhibitor by inhibiting BMP type I receptors ALK2 (IC50=5 nM) and ALK3 (IC50=30 nM)

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PF06447475 - CAS# 1527473-33-1 0197 3-d]pyrimidin-4-olPF06447475, CAS No. 1527473 33 1, is a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD) by genome wide association studies (GWAS). The most common LRRK2 mutation, G2019S, which is relatively rare in the total population, gives rise to increased kinase activity. As such, LRRK2 kinase inhibitors are potentially useful in the