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VTP-27999 TFA - a renin inhibitor. CAS# 1013937-63-7 Size:Solid 2 mg Smiles: CC1N=C(NC(=O)C=1CC)SCC(=O)NC1=NC(=CS1)C1=CC=C(C=C1)OC

VTP-27999 TFA - a renin inhibitor. CAS# 1013937-63-7 Size:Solid 2 mg Smiles: CC1N=C(NC(=O)C=1CC)SCC(=O)NC1=NC(=CS1)C1=CC=C(C=C1)OC

Name: VTP-27999 TFA - a renin inhibitor. CAS# 1013937-63-7 Size:Solid 2 mg Smiles: CC1N=C(NC(=O)C=1CC)SCC(=O)NC1=NC(=CS1)C1=CC=C(C=C1)OC
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VTP-27999 TFA - a renin inhibitor. CAS# 1013937-63-7 Size:Solid 2 mg Smiles: CC1N=C(NC(=O)C=1CC)SCC(=O)NC1=NC(=CS1)C1=CC=C(C=C1)OCVTP 27999 is a highly potent and selective renin inhibitor (IC50 = 0. 47 nM). VTP 27999 demonstrated excellent selectivity over related and unrelated off targets, >15% oral bioavailability in three species, oral efficacy in a double transgenic rat model of hypertension, and good exposure in humans. Product information CAS Number: 1013937 63 7 Molecular Weight: 639. 10 Formula: C28H42ClF3N4O7 Synonym: VTP 27999, 2, 2, 2 trifluoroacetate VTP27999, 2, 2,

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Description

Smiles: CC1N=C(NC(=O)C=1CC)SCC(=O)NC1=NC(=CS1)C1=CC=C(C=C1)OC

2ClH/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14

57(10):4213-38

1-2H3/b8-5+/t14-

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

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