ANA-12 Catalog No.:M8450-10 Magistretti PJ

Magistretti PJ

15 μM for SNU-475 cells and 200 μM for SNU-182 cells

Elsinga PH

An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity

Metformin decreases hepatic glucose production and increases skeletal myocyte glucose uptake

ANA-12 Catalog No.:M8450-10 Magistretti PJANA 12 is aTrkB receptor antagonist. ANA 12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Systemic administration of ANA 12 to adult mice decreased TrkB activity in the brain without affecting neuronal survival. Mice administered ANA 12 demonstrated reduced anxiety and depression related behaviors on a variety of tests predictive of anxiolytic and antidepressant