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AZD1981 hlorophen potent and selective prostanoid EP4

AZD1981 hlorophen potent and selective prostanoid EP4

Name: AZD1981 hlorophen potent and selective prostanoid EP4
Brand: live-language.pl
SKU: 22163256925
Price: 95.00 USD
Availability: InStock
Rating: 4.8181 (28 reviews)

SKU: 22163256925

4.8

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AZD1981 hlorophen potent and selective prostanoid EP4AZD1981is an orally available selective CRTH or DP2 antagonist currently in clinical development for asthma. AZD1981 blocks functional responses in eosinophils, Th2 cells and basophils. AZD1981 displaced radio labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8. 4). Binding was reversible, non competitive and highly selective against a panel of more than 340 other enzymes and receptors, including DP1 (>1000 fold selective). AZD1981

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Description

potent and selective prostanoid EP4 receptor antagonist

02 mM) Ethanol 2 mg/mL (7

the highly drug therapy-resistant missense mutation of Bcr-Abl

It also potently inhibits HDAC1

1021/jm401992e

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