Dinaciclib - CAS# 779353-01-4 ram InChiKey: FQTFHMSZCSUVEU-QRPNPIFTSA-N

InChiKey: FQTFHMSZCSUVEU-QRPNPIFTSA-N

decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines

Z 433927330

29)21(31)14-26(20

InChi: InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36

Dinaciclib - CAS# 779353-01-4 ram InChiKey: FQTFHMSZCSUVEU-QRPNPIFTSA-NDinaciclib, also known as SCH727965, is a potent CDK inhibitor with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC(50) values of 1, 1, 3, and 4 nmol L, respectively. Compared with flavopiridol, Dinaciclib exhibits superior activity with an improved therapeutic index. Dinaciclib induced regression of established solid tumors in a range of mouse models