A01 - Smurf1 E3 Ubiquitin Ligase Inhibitor. CAS# 1007647-73-5 60042 It has general >100-fold selectivity

It has general >100-fold selectivity against other bromodomains including BRPF2

Small Molecule-Mediated TGF-β Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells

Molecular Weight: 419

potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models

InChi: InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2

A01 - Smurf1 E3 Ubiquitin Ligase Inhibitor. CAS# 1007647-73-5 60042 It has general >100-fold selectivityA01, CAS No. 1007647 73 5, is a potent and selective Smurf1 E3 ubiquitin ligase inhibitor with Kd ~3. 7 nM. It attenuates Smurf1 mediated Smad 1 5 degradation and enhances BMP signaling. It also potentiates BMP 2 induced osteoblastic activity in C2C12 myoblasts and MC3T3 E1 osteoblast precursor cells. Product information CAS Number: 1007647 73 5 Molecular Weight: 512. 93 Formula: C22H20ClF3N4O3S Chemical Name: (4 ((4 chloro 3