RU-58841 - CAS# 154992-24-2 G3039 28 nM in ERα binding

28 nM in ERα binding

This effect is potentiated significantly in animals which receive Sacubitril (AHU-377)

while showing no effect on BRPF1A

is a CSF1R inhibitor with IC50 of 20 nM in development by Plexxikon for the treatment of tenosynovial giant cell tumors

the IC50 values are 85 and 63 nM

RU-58841 - CAS# 154992-24-2 G3039 28 nM in ERα bindingRU 58841, CAS No. 154992 24 2, is a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism. The potent localized inhibition of sebaceous glands by RU 58841 demonstrates the excellent potential of this compound as a topical drug for the treatment of acne and other androgen mediated disorders. Product information CAS Number: 154992 24 2 Molecular Weight: 369. 34 Formula: C17H18F3N3O3