KW 2449 nthin 8-1 Coleman RL

Coleman RL

CAS Number: 1202916-90-2

Marbofloxacin has a mycoplasmacidal effect during the exponential phase but not during the lag phase

Molecular Weight: 499

Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2

KW 2449 nthin 8-1 Coleman RLKW 2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I mutated BCR ABL translocation. Recent research showed that HDACIs increase KW 2449 lethality in Bcr Abl(+) cells in association with inhibition of Bcr Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW 2449