PRMT1-2e - Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor. CAS# 17328-16-4 ethyltransferase Lysosomotropism of basic cathepsin K

Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity

Small molecule modulation of Smoothened activity

2013 Aug 27

as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments

CAS Number: 863918-78-9

PRMT1-2e - Protein Arginine Methyltransferase 1 (PRMT1) Inhibitor. CAS# 17328-16-4 ethyltransferase Lysosomotropism of basic cathepsin KPRMT1 2e, CAS No. 17328 16 4, is a potent, specific and cell permeable inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 ~1. 5 M. It has no activity against CARM1 and Set7 9 methyltransferases. It inhibits growth of MCF7a breast cancer cells (IC50 ~1. 97 M) and LNCaP prostate cancer cells (IC50 ~4. 49 M). It can attenuate androgen induced gene expression in LNCaP cells. Product information CAS Number: 17328 16 4 Molecular Weight: