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300 Intravenous Intrajejunal 250 200 Blood Glucose (mg/dL) 150 100 50 0 -30 -15 0 15 30 45 60 75 90 105 120 135 Time (min) A Fundamental Observation: Insulin Secretion is Greater with Oral Compared to IV Glucose Blood Glucose Plasma Insulin 300 IV/IJglucose 250 200 Plasma Insulin ( pmol/L) 150 100 50 0 -30 -15 0 15 30 45 60 75 90 105 120 135 Time (min) Adapted from McIntyre N, et al

The company said products already supplied were unaffected, but the interruption shows that cheaper alternatives will still need to meet the same quality standards as branded drugs

A study by Neale et al (3) reported a 7% prevalence of NMSC in melanoma settings

This side effect may vary in severity and can be influenced by individual health conditions