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Hormonal Changes: Pregnancy, menopause, or medications like birth control can trigger melasma--gray or brown patches on the face

The consequent impact on spermatogenesis is profound, resulting in significantly reduced sperm count, motility, and increased sperm abnormalities and DNA fragmentation, which collectively impair fertilization potential and embryo development 11

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They suppress or dysregulate the innate immune response, impair the adaptive immune response, and damage the mucosal barriers of the gut and respiratory tract