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Malespin MH, Barritt AS, Watkins SE et al (2022) Weight loss and weight regain in usual clinical practice: results from the TARGET-NASH observational cohort

Rotating injection sites and attending regular follow-up appointments further optimise treatment outcomes

Upon analysis, researchers found that participants who took GLP-1 medications experienced significant neurological and behavioral health benefits, including a reduced risk of substance addiction to alcohol, cannabis, opioids, and stimulants, compared to those taking traditional diabetes medications

Receptor binding affinity (EC??, Human) = ~0.135 nM GLP-1 Receptor (GLP-1R) Agonism Stimulates glucose-dependent insulin secretion: Enhances insulin release and lowers glucagon during hyperglycemia 1

While semaglutide lowers glucose in people with diabetes, non-diabetic individuals experience the appetite-suppressing benefits regardless of baseline glucose levels