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To enable rigorous cross-platform evaluation and to address reviewer concerns regarding quantitative comparisons, Table 2 now consolidates standardized transport/penetration metrics (e.g., penetration distance, spatial coverage/distribution surrogates, and tumor exposure-type readouts when reported) and explicitly states the comparator arm for each readout (e.g., PBS/vehicle, free drug, or non-transformable nanocarriers)

Increased TMAO levels in addition to endothelial dysfunction, vascular aging, and oxidative stresses have been shown to cause thrombotic events and platelet excitability in humans, which in turn induce atherosclerosis [69, 72]

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Generally well tolerated Rare skin sensitivity in some individuals Should not be used during pregnancy or breastfeeding Requires licensed provider supervision for injectable form All prescriptions are issued by a licensed US provider after reviewing your intake