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Additionally, sitagliptin has been shown to lower the proinsulin-to-insulin ratio (an indicator of -cell function) and increase the homeostasis model assessment-B index, a measure of insulin production (49, 50)

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The capability of Sp to replenish reduced glutathione levels was further tested in neuronal cells exposed to MPP + , the toxic bioactivation product of MPTP known to induce Parkinsonian phenotype in animal models 1