CLLU1 Rabbit Polyclonal Antibody, 100ul Bottles disease:Defects in GRN are the

disease:Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD)

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily

Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation

The encoded protein binds to the interferon alpha/beta receptor but not to the interferon gamma receptor

and thus represents a nonreceptor-type isoform of this PTP

CLLU1 Rabbit Polyclonal Antibody, 100ul Bottles disease:Defects in GRN are theThe protein encoded by this gene is overexpressed in chronic lymphocytic leukemia (CLL) and serves as a good prognostic marker for the disease. Methylation of certain genes including this one have been associated with CLL. This gene is protein coding in humans and non protein coding in other primates. Three transcript variants one protein coding and the other two non protein coding have been found for this gene.