WIPI2 Rabbit Polyclonal Antibody, 50ul Biomatrix The large catalytic subunit has

The large catalytic subunit has four domains: domain I

Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences

a protein involved in the nucleotide excision repair (NER)

Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization| inositol triphosphate production and secretion of IL6 and CSF1

It is induced by heat shock and treatment with the HSP 90 inhibitor 17-demeth-oxygeldanamycin

WIPI2 Rabbit Polyclonal Antibody, 50ul Biomatrix The large catalytic subunit hasWD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta propeller platform for simultaneous and reversible protein protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7 bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas Cezanne et al., 2004