Phospho-Akt (Y315) Polyclonal Antibody, 100ul Peptide Library POLE4 is a histone-fold protein

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner

This protein cleaves and activates caspases 3 and 7| and the protein itself is processed by caspase 8

GO annotations related to this gene include phosphatase binding

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This gene is adjacent to another family member CLDN9 on chromosome 16

Phospho-Akt (Y315) Polyclonal Antibody, 100ul Peptide Library POLE4 is a histone-fold proteinThe serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3 kinase. In the developing nervous system AKT is a