c-Abl Rabbit Polyclonal Antibody, 100ul Pathway and Network Analysis Mutations in this gene have

Mutations in this gene have been associated with thrombophilia due to protein C deficiency| neonatal purpura fulminans| and recurrent venous thrombosis

and may be related to tumor metastasis

but not for neutrophils

|enzyme regulation:Strongly inhibited by TIMP-2| TIMP-3 and TIMP-4| while TIMP-1 is less efficient

tissue specificity:Appears to be expressed ubiquitously

c-Abl Rabbit Polyclonal Antibody, 100ul Pathway and Network Analysis Mutations in this gene haveThis gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA binding activity that is regulated by CDC2 mediated phosphorylation,