Stat2 (Acetyl Lys384) Rabbit Polyclonal Antibody, 100ul Transporters This subunit can be phosphorylated

This subunit can be phosphorylated by the activated catalytic subunit

thus inhibiting SMAD3-mediated TGF-beta responses

Lambda 5 is critical for B cell development in mammals

the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor

5mL to 100mL

Stat2 (Acetyl Lys384) Rabbit Polyclonal Antibody, 100ul Transporters This subunit can be phosphorylatedSignal transducer and activator of transcription that mediates signaling by type I IFNs (IFN alpha and IFN beta). Following type I IFN binding to cell surface receptors Jak kinases (TYK2 and JAK1) are activated leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize associate with ISGF3G IRF 9 to form a complex termed ISGF3 transcription factor that enters the nucleus. ISGF3 binds to the IFN stimulated response