ERCC1 Polyclonal Antibody, 50ul Vacuum Aspirator The integrator complex associates with

The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2

which catalyzes the release of large hydrophobic C-terminal amino acids

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ERCC1 Polyclonal Antibody, 50ul Vacuum Aspirator The integrator complex associates withThe product of ERCC1 functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in