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The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children

It is most closely related to MAPK8

Two transcript variants

OPA1 Polyclonal Antibody, 20ul Micro Centrifuge Tubes Boost your lab work toThis gene product is a nuclear encoded mitochondrial protein with similarity to dynamin related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.