CD63 Polyclonal Antibody, 50ul[BT-AP02139] Microplate Mixer Two transcripts that encode the

Two transcripts that encode the same protein have been identified for this gene

This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption

The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting

and can bind the class III Arf ARF6 without immediate GAP activity

An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714)

CD63 Polyclonal Antibody, 50ul[BT-AP02139] Microplate Mixer Two transcripts that encode theCortactin, encoded by CTTN gene (formerly EMS1), was originally identified as a substrate of the Src kinase. It is a cytoskeletal protein that interacts with F actin and Arp2 3 complex and plays an important role in regulation of actin assembly and cytoskeleton dynamics. Overexpression of cortactin increases cell migration, and is thought to contribute to the invasive phennotype of breast cancer and several other tumors. Three isoforms of cortactin