Human Alpha-2-Macroglobulin-like Protein 1, A2ML1 ELISA Kit , 96T Immune Repertoire Sequencing RFWD2 (Ring Finger And WD

RFWD2 (Ring Finger And WD Repeat Domain 2) is a Protein Coding gene

followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain

The encoded protein is a highly specific ubiquitin iso-peptidase

signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity)

Gene Ontology (GO) annotations related to this gene include L-serine transmembrane transporter activity

Human Alpha-2-Macroglobulin-like Protein 1, A2ML1 ELISA Kit , 96T Immune Repertoire Sequencing RFWD2 (Ring Finger And WDIs able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a Peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight