Porcine Caspase-3, CASP3 ELISA Kit, 96T Cell Culture Plates are integral membrane proteins containing

are integral membrane proteins containing 7 putative transmembrane domains (TMs)

May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity

An important paralog of this gene is AATK

Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC

Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3)

Porcine Caspase-3, CASP3 ELISA Kit, 96T Cell Culture Plates are integral membrane proteins containingInvolved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP ribose) polymerase (PARP) at a '216 Asp Gly 217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix loop helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase 6, 7 and 9. Involved in the cleavage of huntingtin.