KIAA0649 Rabbit Polyclonal Antibody, 50ul Antibody Development Unlike other proteins of the

Unlike other proteins of the group| which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes| the protein encoded by this gene is a non-cycling resident protein of the ER| where it functions as a cargo receptor for glycoproteins

Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration

The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments

and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus

which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis

KIAA0649 Rabbit Polyclonal Antibody, 50ul Antibody Development Unlike other proteins of the