DOCK 2 Polyclonal Antibody, 50ul Drug Development and Evaluation Mutations in this gene cause

Mutations in this gene cause spinocerebellar ataxia type 15

this protein is localized to the cytoplasm of primary spermatocytes

an active X chromosome homolog of the Y chromosome RBMY gene

SLCO1B1 encodes a liver-specific member of the organic anion transporter family

Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity

DOCK 2 Polyclonal Antibody, 50ul Drug Development and Evaluation Mutations in this gene causeDedicator of cytokinesis protein 2 encoded by DOCK2 belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long term survival