Dkk-3 Polyclonal Antibody, 100ul Cellular Function Assays This gene encodes the alpha

This gene encodes the alpha subunit

Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor

Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II)

Pseudogenes have been identified on chromosomes 6 and 11

The protein encoded by this gene belongs to the GHMP (galacto-

Dkk-3 Polyclonal Antibody, 100ul Cellular Function Assays This gene encodes the alphaDKK3 encodes dickkopf WNT signaling pathway inhibitor 3 that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of DKK3 is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.