LPL Monoclonal Antibody, 50ul Electronic Pipette a highly penetrant familial cancer

a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53

Mutations in this gene cause ovarian dysgenesis type 1

Four transcript variants encoding the same protein have been identified for this gene

Overexpression of BCL2L12 has been detected in a number of different cancers

suggesting a role in leukemogenesis

LPL Monoclonal Antibody, 50ul Electronic Pipette a highly penetrant familial cancerLPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand bridging factor for receptor mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.