TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation Charcot-Marie-Tooth disease

Charcot-Marie-Tooth disease

this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas

growth control

which regulates its nuclear matrix and chromatin association

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules

TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody, 20ul Cell Dissociation Charcot-Marie-Tooth diseaseCatalytic activity: ATP dependent breakage passage and rejoining of double stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils whereas prokaryotic enzymes relax only