Survivin Polyclonal Antibody, 20ul[BT-AP14596] Diagnostic Probes & Oligos TOP2A encoding this enzyme functions

TOP2A encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance

It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell

Members of this family play a role in several cellular processes

The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors

Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS)

Survivin Polyclonal Antibody, 20ul[BT-AP14596] Diagnostic Probes & Oligos TOP2A encoding this enzyme functionsThis gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues.