EP-CAM Polyclonal Antibody, 50ul[BT-AP02986] Culture Plate Inserts Translocations between this gene on

Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia

Several alternatively spliced transcript variants have been found for this ATF2

subunit:Interacts with GIPC PDZ domain

CRKL encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion

consisting of several homo- and heterodimers of alpha

EP-CAM Polyclonal Antibody, 50ul[BT-AP02986] Culture Plate Inserts Translocations between this gene onEPCAM encodes a carcinoma associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in EPCAM result in congenital tufting enteropathy.