PD-L2 Polyclonal Antibody, 20ul Modification Enzymes The CDK8 subcomplex modulates Mediator-polymerase

The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates

Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity)

The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion

Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19

Multiple transcript variants encoding different isoforms have been identified for this gene

PD-L2 Polyclonal Antibody, 20ul Modification Enzymes The CDK8 subcomplex modulates Mediator-polymeraseInvolved in the costimulatory signal, essential for T cell proliferation and IFNG production in a PDCD1 independent manner. Interaction with PDCD1 inhibits T cell proliferation by blocking cell cycle progression and cytokine production.,induction: Up regulated by IFNG stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4.,Belongs to the immunoglobulin superfamily. BTN MOG