BNIP-3 Polyclonal Antibody, 50ul[BT-AP00948] Insect Expression Alternative splicing has been observed

Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats

such as RALGDS

which contains one PH domain and one SH2 domain

One isoform lacks the intermembrane region and is secreted outside the cell

Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome

BNIP-3 Polyclonal Antibody, 50ul[BT-AP00948] Insect Expression Alternative splicing has been observedBNIP3 (BCL2 interacting protein 3) is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro apoptotic factor. The encoded protein interacts with anti apoptotic proteins, including the E1B 19 kDa protein and Bcl2. BNIP3 is silenced in tumors by DNA methylation.