WWOX Polyclonal Antibody, 50ul Recombinant Ab Production and are clustered together on

and are clustered together on chromosome X

The protein

The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER

Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates

An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing

WWOX Polyclonal Antibody, 50ul Recombinant Ab Production and are clustered together onWWOX (WW domain containing oxidoreductase) encodes a member of the short chain dehydrogenases reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia