Scribble(Phospho-Ser1220) Rabbit Polyclonal Antibody, 100ul Enzyme Activity Assays The heterodimer

The heterodimer

Hyperphosphorylation of Rb proteins results in a loss of E2F binding and allows for transcriptional activation and cell cycle progression

a zinc-binding B-box motif

The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail

The signalling and trafficking of this receptor are regulated by multiple factors| including Rab GTPase| P2Y purine nucleotide receptor| integrin alphaVbeta3| T-cell protein tyrosine phosphatase| etc

Scribble(Phospho-Ser1220) Rabbit Polyclonal Antibody, 100ul Enzyme Activity Assays The heterodimerThis gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms