CEA16 Polyclonal Antibody, 100ul Drying & Desiccation Several alternatively spliced transcript variants

Several alternatively spliced transcript variants have been found for CHEK1

Alternative splicing of this gene results in two transcript variants encoding different isoforms

Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor

shown here

A serine-rich region promotes activation of the serum response element (SRE)

CEA16 Polyclonal Antibody, 100ul Drying & Desiccation Several alternatively spliced transcript variantsThe protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non syndromic autosomal dominant hearing loss.