Nucleophosmin Polyclonal Antibody, 50ul Cell Culture Dishes Mutations in this gene have

Mutations in this gene have been associated with insulin-dependent diabetes mellitus

An important paralog of this gene is ADGRG7

The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance

PML is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL)

cofactor:Binds 2 zinc ions per subunit

Nucleophosmin Polyclonal Antibody, 50ul Cell Culture Dishes Mutations in this gene haveNPM1 encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in NPM1 are associated with acute myeloid leukemia. More than a dozen pseudogenes of NPM1 have been identified. Alternative