GDF-5 Polyclonal Antibody, 100ul Mammalian Expression The protein contains a series

The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus

Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma

It is secreted by gastric chief cells in the fundic mucosa of the stomach| and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions

Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin

Two additional variants have been described| but their full length sequences have not been determined

GDF-5 Polyclonal Antibody, 100ul Mammalian Expression The protein contains a seriesGDF5 encodes a secreted ligand of the TGF beta (transforming growth factor beta) superfamily of proteins. Ligands of this family bind various TGF beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide linked homodimer. Growth differentiation factor 5 regulates the development of numerous